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Javadov, Sabzali

One or more keywords matched the following properties of Javadov, Sabzali

Property	Value
overview	I have a broad background in medical biochemistry, with specific training and expertise in cardiac pathophysiology, with a focus on the roles of mitochondria in ischemia-reperfusion (IR), heart failure, and aging. My studies have been conducted on various model systems using in vivo (myocardial infarction in dogs and rats, alloxan-induced diabetes in rabbits), ex-vivo (global IR in Langendorff-perfused isolated rat and mouse heart), and in vitro (hypertrophy, hypoxia/reoxygenation in cultured cells) models. Different pharmacological agents and conditional approaches have been used in my studies to prevent mitochondria-mediated cell death in cardiac diseases. Since 1997, my research focuses on the role of mitochondrial permeability transition pore (PTP) opening and mitochondrial swelling during cardiac IR injury and post-myocardial infarction heart failure. I successfully administered several projects in Europe, Canada, and PR, collaborated with other researchers, and produced several peer-reviewed publications from each project. Currently, my research is supported by NIH and NSF grants.

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Value

overview

I have a broad background in medical biochemistry, with specific training and expertise in cardiac pathophysiology, with a focus on the roles of mitochondria in ischemia-reperfusion (IR), heart failure, and aging. My studies have been conducted on various model systems using in vivo (myocardial infarction in dogs and rats, alloxan-induced diabetes in rabbits), ex-vivo (global IR in Langendorff-perfused isolated rat and mouse heart), and in vitro (hypertrophy, hypoxia/reoxygenation in cultured cells) models. Different pharmacological agents and conditional approaches have been used in my studies to prevent mitochondria-mediated cell death in cardiac diseases. Since 1997, my research focuses on the role of mitochondrial permeability transition pore (PTP) opening and mitochondrial swelling during cardiac IR injury and post-myocardial infarction heart failure. I successfully administered several projects in Europe, Canada, and PR, collaborated with other researchers, and produced several peer-reviewed publications from each project. Currently, my research is supported by NIH and NSF grants.

One or more keywords matched the following items that are connected to Javadov, Sabzali

Item Type	Name
Academic Article	Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases.
Academic Article	Targeting the mitochondrial permeability transition: cardiac ischemia-reperfusion versus carcinogenesis.
Academic Article	The role of PPARa in metformin-induced attenuation of mitochondrial dysfunction in acute cardiac ischemia/reperfusion in rats.
Academic Article	Angiotensin II and ischemic preconditioning synergize to improve mitochondrial function while showing additive effects on ventricular postischemic recovery.
Academic Article	Mitochondrial permeability transition in cardiac ischemia-reperfusion: whether cyclophilin D is a viable target for cardioprotection?
Academic Article	The Role of SIRT3 in Mediating Cardioprotective Effects of RAS Inhibition on Cardiac Ischemia-Reperfusion.
Academic Article	Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia-Reperfusion.
Academic Article	Angiotensin II-preconditioning is associated with increased PKCe/PKCd ratio and prosurvival kinases in mitochondria.
Academic Article	Critical role of angiotensin II type 2 receptors in the control of mitochondrial and cardiac function in angiotensin II-preconditioned rat hearts.
Academic Article	Mitochondrial angiotensin receptors and cardioprotective pathways.
Academic Article	The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury.
Academic Article	Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart.
Academic Article	NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition.
Academic Article	Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection.
Concept	Reperfusion Injury
Concept	Myocardial Reperfusion Injury
Academic Article	[Energy metabolism and contractile function of the heart in diabetic cardiomyopathy: effect of ischemia and reperfusion].
Academic Article	[Quantitative relationship between ischemic heart disease and parameters of energy metabolism].
Academic Article	Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition.
Academic Article	Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart.
Academic Article	Association Between L-OPA1 Cleavage and Cardiac Dysfunction During Ischemia-Reperfusion Injury in Rats.
Academic Article	Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spectrometry (GCIB-SIMS).

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